| Title: | GS4-3 Boolean modeling of mammalian cell cycle and cancer pathways |
|---|---|
| Publication: | ICAROB2017 |
| Volume: | 22 |
| Pages: | 507-510 |
| ISSN: | 2188-7829 |
| DOI: | 10.5954/ICAROB.2017.GS4-3 |
| Author(s): | Hideaki Tanaka, Adrien Fauré, Hiroshi Matsuno |
| Publication Date: | January 19, 2017 |
| Keywords: | Boolean modeling, Cell cycle, Cancer pathways |
| Abstract: | The cell division cycle is controlled by a complex molecular network: a recent model of the cell cycle and cancer pathways includes close to a hundred genes [Fumiã and Martins, 2013]. To cope with such complexity, different approaches have been used by modelers. Recently, Deritei et al [2016] have emphasized modularity as a key organizational principle. Their model however, includes only 21 components. This raises the question how the approach would fare on larger models such as the one published by Fumiã and Martins.To explore that question we first convert these two models to a common modeling framework [Naldi et al., 2009]. Preliminary results show that there is only limited overlap between the two models, with shared variables being controlled by different regulators. This suggests that at this stage module definition may still depend on the modeler and thus may not yet reflect actual biological organization. |
| PDF File: | https://alife-robotics.co.jp/members2017/icarob/data/html/data/GS_pdf/GS4/GS4-3.pdf |
| Copyright: | © The authors. This article is distributed under the terms of the Creative Commons Attribution License 4.0, which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. See for details: https://creativecommons.org/licenses/by-nc/4.0/ |
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