| Title: | GS4-2 Behavior Analysis on Boolean and ODE models for Extension of Genetic Toggle Switch from Bi-stable to Tri-stable |
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| Publication: | ICAROB2017 |
| Volume: | 22 |
| Pages: | 502-506 |
| ISSN: | 2188-7829 |
| DOI: | 10.5954/ICAROB.2017.GS4-2 |
| Author(s): | Masashi Kubota, Manabu Sugii, Hiroshi Matsuno |
| Publication Date: | January 19, 2017 |
| Keywords: | synthetic biology, artificial genetic circuit, |
| Abstract: | The artificial genetic circuit (AGC) is a gene network in which its expression timing, period and function are designed by computational and biological techniques. The AGCs for the functions of electronic circuits like a toggle switch and an oscillation circuit were realized in E.coli by Gardner and Elowitz in 2000[1],[2], respectively. We visualized and verified the structure and behavior of Boolean network (BN) and ordinary differential equation (ODE) models for 2-variable genetic toggle switch in the phase plane by using GINsim and Scilab. ODE is the most widely used formalism for biological processes, while BN model allows us to easily understand mathematical expression of biological processes. Then, we extended the models to 3-variable genetic toggle switch from the 2-variable ones demonstrating a mathematical formalization by showing correspondence between state transitions of BN and trajectory paths of ODEs in the phase space. |
| PDF File: | https://alife-robotics.co.jp/members2017/icarob/data/html/data/GS_pdf/GS4/GS4-2.pdf |
| Copyright: | © The authors. This article is distributed under the terms of the Creative Commons Attribution License 4.0, which permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. See for details: https://creativecommons.org/licenses/by-nc/4.0/ |
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